Thanks to vaccination and new treatments bacterial and viral diseases have been controlled. Modern day vets see far more dogs suffering from genetic disorders. A genetic disorder results from an abnormality in the genome of the individual, inherited or in which inheritance seems to play a major role. These genetic disorders are quite frequent in purebred dogs. Almost 480 inherited diseases have been identified in the dog. Whereas in human inherited diseases frequency does not exceed 0,1%, many canine inherited diseases have a frequency going from 10 to 50% in the affected breeds. There is an urgent need for tools reducing the frequency of inherited diseases in the dog population and this will be one of the first achievements of the LUPA project.